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PE 22-28 peptide: Cognitive / Neuro research guide

In short: PE 22-28 is a seven-residue peptide derived from spadin (PE 12-28), the sortilin-propeptide fragment studied as a TREK-1 (K2P) channel blocker in rodent models. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.

Not medical advice. PE 22-28 is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.

PE 22-28 at a glance

Compound type

Research peptide

Research category

Cognitive / Neuro

Also known as

PE 22-28, PE22-28, spadin fragment, spadin-derived heptapeptide

Evidence context

Preclinical / research use only

Regulatory status

Not an approved medicine. Supplied as a research compound

Last reviewed

13 October 2026

What to know first

Compound PE 22-28 Research class Cognitive / Neuro Available pack sizes 10 × 10 mg Storage Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight.

Details and limits sit in the sections below. Research use only. No unsupported scientific claims are added here.

What PE 22-28 is

PE 22-28 is a seven-residue peptide cut down from spadin, the sortilin-propeptide fragment studied as a TREK-1 potassium channel blocker in rodent research.

One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.

PE 22-28 is a seven-residue peptide derived from spadin (PE 12-28), the sortilin-propeptide fragment studied as a TREK-1 (K2P) channel blocker in rodent models.

Research contexts

Peer-reviewed papers discuss PE 22-28 in specific lab settings. The points below reflect research questions, not health claims.

Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.

Typical study contexts

Stress, sleep and neuronal signalling in rodents.

Some compounds appear in small exploratory human studies elsewhere. Still not DIY use.

Seven-residue fragment (propeptide positions 22-28) derived from spadin, PE 12-28.

Characterised by patch-clamp on a human TREK-1 HEK cell line, with a reported IC50 near 0.1 nM against about 40 nM for spadin.

Compared with spadin for persistence in mouse serum and in mice.

Reference peptide for TREK-1 (K2P) channel pharmacology in rodent behavioural-model research.

Why Cognitive / Neuro research matters

Cognitive-related peptides are explored for stress pathways and neuronal signalling in animals. Not treatments for human brain conditions.

Mechanisms (technical review)

Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.

Seven-residue fragment (propeptide positions 22-28) derived from spadin, PE 12-28

Characterised by patch-clamp on a human TREK-1 HEK cell line, with a reported IC50 near 0.1 nM against about 40 nM for spadin

Compared with spadin for persistence in mouse serum and in mice

Reference peptide for TREK-1 (K2P) channel pharmacology in rodent behavioural-model research

Single 10 mg strength; sealed 10-vial pack or one-vial sample

Lab handling & preparation

Storage: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight.. See the storage guide.

Published pharmacokinetic context: Laboratory research material. No amount, schedule or administration guidance is published or recommended on this page.

Purity check: Use the COA reading guide and the published Certificates of Analysis (no current certificate is listed for PE 22-28 yet).

Common Questions People Are Asking

What is PE 22-28?

PE 22-28 is a seven-residue peptide derived from spadin, covering positions 22 to 28 of the sortilin propeptide. It was studied as a TREK-1 channel inhibitor in cells and mice. This page supplies it as laboratory research material only.

How does it differ from spadin?

Spadin spans positions 12 to 28 of the propeptide; PE 22-28 is the shorter seven-residue fragment. In the 2017 paper it inhibited TREK-1 currents at a lower concentration than spadin and its action was reported to last longer in mice.

Is there human research on PE 22-28?

No controlled human data are cited on this page. The studies cited used a human TREK-1 cell line and mice, and their results do not establish effects in people.

Why is the sequence not listed?

The residue letters, formula and molecular weight could not be confirmed from the cited papers, so they are left out rather than guessed.

What does the single-vial sample contain?

One 10 mg vial of the same lyophilised research material as the sealed 10-vial pack, for in-vitro and preclinical use only.

Is this page medical advice? Can I use PE 22-28 for my health?

No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.

Where do I find PE 22-28 specs, purity certificates and pricing?

Open the shop listing via “View product details.” There you will see concentration, purity grade, and available SKUs with current pricing. No current Certificate of Analysis is published for PE 22-28 yet; published certificates are listed at /coa.

Related peptide guides

Other compounds researchers often read about alongside PE 22-28.

Selank: Cognitive / Neuro research guide

Semax: Cognitive / Neuro research guide

Cerebrolysin: Cognitive / Neuro research guide

DSIP: Cognitive / Neuro research guide

Adamax: Cognitive / Neuro research guide

Continue PE 22-28 research

Analytical evidence, comparisons and current research for this compound. Research use only.

Research area Cognitive & longevity research The neuropeptide and longevity research area - nootropic and geroprotective peptides and related compounds studied in cognition… Explore the research area →

Scientific sources & further reading

Primary literature and registries for PE 22-28, plus mainstream coverage of the peptide category. Research use only - not medical advice.

Databases & literature:

PubMed: peer-reviewed literature on PE 22-28

ClinicalTrials.gov: registered studies on PE 22-28

PE 22-28: Wikipedia (search)

Peptides in the news:

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

Sky News Australia: “Backyard peptide boom sparks alarm” (video)

Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

Ready to order? View full product specs

Access concentration, batch info, variants, and current pricing on our shop.

Also known as: PE 22-28, PE22-28, spadin fragment, spadin-derived heptapeptide

PRECISION. PURITY. PERFORMANCE.

Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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