Buy Cardiogen (AEDR) Peptide Bioregulator

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Vial strength 20 mg In stock. Pick one in the selector.

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Cardiogen

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Scientific Research Context

What the published literature on Cardiogen examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Cytoskeletal and nuclear-matrix proteins

In cultured mouse embryonic fibroblasts, AEDR was reported to raise expression of actin, tubulin and vimentin about 2-5 fold and of lamin A and C about 2-3 fold. The authors link this to proliferation and anti-apoptotic effects. [in vitro]

Myocardial explants

Organotypic cultures of heart tissue from 3- and 24-month-old rats grew more with the peptide present, with lower p53 immunostaining. [ex vivo, rat tissue]

Tissue matching

In explants of heart, lung, prostate and pancreas from young and old rats, each of four peptides stimulated growth only in its matching tissue; cardiogen was paired with heart. [ex vivo, rat tissue]

Fibroblast signalling in human cells

Cardiogen was reported, alongside two other peptides, to raise CXCL12, WEDC1 and ghrelin expression in cultures of aged human prostate fibroblasts. [in vitro, human cells]

Scientific Overview

In short: Cardiogen (Ala-Glu-Asp-Arg, "AEDR") is a four-residue synthetic peptide from the Khavinson bioregulator family, studied for cytoskeletal gene expression in cultured cells and growth of heart-tissue explants.

Key research facts

Synthetic Ala-Glu-Asp-Arg (AEDR) tetrapeptide from the Khavinson short-peptide lineage

Studied for expression of actin, tubulin, vimentin and nuclear lamins in cultured fibroblasts

Examined in organotypic myocardial explants from young and old rats

Tested alongside Bronchogen, Prostamax and Pancragen for tissue-matched explant growth

Shares the Ala-Glu-Asp stem with Cartalax and Epitalon

These points summarise lab themes, not human outcomes.

AEDR is Cartalax (Ala-Glu-Asp) with arginine added at the end, and it differs from Epitalon (Ala-Glu-Asp-Gly) only at the last residue. The Khavinson programme matches each short peptide to a tissue and assigns this one to the myocardium. The name-to-sequence link rests on the group's own review tables and the patent, and the primary papers use the name "cardiogen" without printing the sequence in their abstracts.

The published record is thin but varied. A 2012 study found that the tetrapeptide raised expression of actin, tubulin and vimentin roughly two- to five-fold and of lamins A and C two- to three-fold in cultured mouse embryonic fibroblasts. Organotypic culture work on rat heart tissue reports stimulated growth and lower p53 staining in explants from young and old animals, and in a four-tissue study cardiogen stimulated growth in heart explants and not in the other three tissues.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Ala-Glu-Asp-Arg (AEDR)

Research focus: Cytoskeletal and nuclear-matrix protein expression; myocardial tissue explants

Evidence base: Cell-culture and ex-vivo rat tissue studies, mostly from one research network; no human data

Cardiogen is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Arg (AEDR), developed in the Khavinson short-peptide programme and covered by a 2004 Russian patent priority. It is the heart-tissue member of the family. Published work reports raised expression of actin, tubulin, vimentin and lamins in cultured mouse embryonic fibroblasts and growth of heart-tissue explants from young and old rats, and in a multi-tissue explant study it stimulated growth in heart tissue only. It is supplied as lyophilised powder strictly for in-vitro and preclinical research. Not for human or veterinary use.

At a glance

Compound identity Synthetic short-peptide bioregulator (Khavinson family)

Primary research focus Cytoskeletal and nuclear-matrix protein expression; myocardial tissue explants

Mechanism and receptors Cardiogen is studied as a tissue-matched modulator of structural-protein expression. The proposed model is nuclear uptake and DNA or histone binding; the evidence is expression data in culture plus fluorescence and docking studies.

Experimental models Growth and p53 staining in myocardial explants from young and old rats; Tissue-matched explant growth across heart, lung, prostate and pancreas (rat organotypic culture).

Molecular characteristics Molecular weight 489.49 Da; sequence Ala-Glu-Asp-Arg.

Evidence maturity Tier 3: Limited / anecdotal — Cardiogen has a small preclinical record of fibroblast-culture and rat explant studies, four of five peptide-specific papers from the originating network and none independent. There are no human data. The name-to-sequence assignment rests on the group's own reviews and a patent. It is supplied as unapproved laboratory material.

Research limitations Most published findings come from cell and animal models; they cannot be treated as evidence of human efficacy or safety.

Proposed Mechanism

Cardiogen is studied as a tissue-matched modulator of structural-protein expression. The proposed model is nuclear uptake and DNA or histone binding; the evidence is expression data in culture plus fluorescence and docking studies.

Pathway Effect Why it matters Cytoskeletal expression Actin, tubulin and vimentin raised in mouse embryonic fibroblasts Proposed link to cell proliferation and survival in culture Nuclear-matrix expression Lamin A and C raised about two- to three-fold Lamins organise chromatin; a candidate route for transcriptional effects Tissue-matched growth Stimulated heart explants, not lung, prostate or pancreas explants The core evidence for the tissue-matching idea in this family Histone binding and transporter docking AEDR bound wheat histones in a cell-free assay and was predicted to dock LAT1, LAT2 and PEPT1 Computational and cell-free support only; no transport was measured

Deeper dive for scientific readers

The group proposes that ultrashort peptides cross the membrane through peptide or amino-acid transporters and act on chromatin. For AEDR the supporting measurements are the fibroblast expression data, the explant growth work, a fluorescence-quenching assay against FITC-labelled wheat histones, and docking scores. The patent also describes cardiac models in rodents, but a patent is not peer-reviewed and its outcomes are not reproduced here. The cardiac assignment of the name Cardiogen is made in the group's reviews, which cite the patent; a review also states that AEDR was detected in a heart polypeptide complex without giving a primary source.

Common Questions People Are Asking

What is Cardiogen?

Cardiogen is the name used for the synthetic tetrapeptide Ala-Glu-Asp-Arg (AEDR) from the Khavinson short-peptide programme, which pairs it with heart tissue. It is supplied here as a laboratory research powder only.

What does the research on Cardiogen show?

In cultured mouse fibroblasts it was reported to raise actin, tubulin, vimentin and lamin expression. In rat tissue explants it stimulated growth of heart tissue, and in a four-tissue comparison it stimulated heart tissue only. All of it is preclinical and the peptide-specific papers are mostly from one research network.

Why is Cardiogen hard to look up?

The name collides with other products. A chemical-database search for "cardiogen" returns carnitine, and most PubMed hits are about a rubidium-82 generator. Look it up by sequence (Ala-Glu-Asp-Arg) instead.

Is there human data on Cardiogen?

No human study was found in the literature cited here. Cardiogen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Cardiogen?

Right here - Cardiogen is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Cardiogen cost?

Cardiogen pricing is shown live on this page, per pack size - sealed 10-vial research packs, or single vials where listed (an order needs at least 5 single vials in total, or any 10-vial pack). Shipping is free on orders over $350.

How do I buy Cardiogen?

Add the Cardiogen pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Cardiogen?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Cardiogen?

In the United States, Cardiogen is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Cardiogen has a small preclinical record of fibroblast-culture and rat explant studies, four of five peptide-specific papers from the originating network and none independent. There are no human data. The name-to-sequence assignment rests on the group's own reviews and a patent. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Growth and p53 staining in myocardial explants from young and old rats

Tissue-matched explant growth across heart, lung, prostate and pancreas (rat organotypic culture)

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med 2012. · 2012 · PMID: 22977870 · DOI: 10.1007/s10517-012-1766-9

Chalisova NI, Lesniak VV, Balykina NA, et al. The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats. Adv Gerontol 2009. · 2009 · PMID: 20210190

Zakutskii AN, Chalisova NI, Ryzhak GA, et al. The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats. Adv Gerontol 2006. · 2006 · PMID: 17152728

Kheifets OV, Poliakova VO, Kvetnoi IM. Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging. Adv Gerontol 2010. · 2010 · PMID: 20586252

Fedoreyeva LI, Smirnova TA, Kolomijtseva GY, et al. Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides. Biochemistry (Mosc) 2013. · 2013 · PMID: 23581987 · DOI: 10.1134/S0006297913020053

Khavinson VK, Linkova NS, Rudskoy AI, et al. Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters. Biomolecules 2023. · 2023 · PMID: 36979488 · DOI: 10.3390/biom13030552

PubMed: peer-reviewed literature on Cardiogen

ClinicalTrials.gov: registered studies on Cardiogen

Cardiogen: Wikipedia (search)

WebMD: consumer health reference

BBC News: Health

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Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

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Key Characteristics

Four-residue peptide: Ala-Glu-Asp-Arg (AEDR)

Cartalax (Ala-Glu-Asp) plus a C-terminal arginine

Differs from Epitalon (Ala-Glu-Asp-Gly) at the last residue only

Cytoskeletal expression and rat heart-explant data

No human data; evidence from one research network

Supplied as sealed 10-vial packs of 20 mg lyophilised vials, or as single vials

Specifications

Sequence Ala-Glu-Asp-Arg (AEDR) Residues 4 Molecular Formula C 18 H 31 N 7 O 9 Molecular Weight 489.49 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Cardiogen (AEDR): Short-Peptide Bioregulator Research Guide

Searching for Cardiogen by name alone is unreliable. In chemical databases the name returns carnitine, and in PubMed most hits are about an unrelated rubidium-82 generator sold under a similar name. The peptide is Ala-Glu-Asp-Arg, and it is found by sequence. The Russian priority application for the peptide substance dates to June 2004, with a United States grant in 2010 (US 7,662,789 B2).

The peptide-specific literature is small. The papers cited here cover cytoskeletal protein expression in fibroblasts, an organotypic study on rat heart tissue, a multi-tissue explant comparison, and a study of fibroblast signalling factors in aged human prostate cultures.

New-U Research Compounds supplies Cardiogen as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med 2012.

Chalisova NI, Lesniak VV, Balykina NA, et al. The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats. Adv Gerontol 2009.

Zakutskii AN, Chalisova NI, Ryzhak GA, et al. The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats. Adv Gerontol 2006.

Kheifets OV, Poliakova VO, Kvetnoi IM. Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging. Adv Gerontol 2010.

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Research guide Cardiogen research guide Cardiogen is studied as a tissue-matched modulator of structural-protein expression. Read the guide →

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