Buy Ovagen (EDL, T-35) Peptide Bioregulator

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Vial strength 20 mg In stock. Pick one in the selector.

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Form Lyophilised powder Supplied in sealed vials. Storage conditions are listed in the specifications.

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Ovagen

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Scientific Research Context

What the published literature on Ovagen examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Rat kidney-injury models

In gentamicin-induced and ischemia-reperfusion kidney injury in rats, EDL was reported to prevent oliguria and retention azotemia, reduce proteinuria and sodium excretion, preserve antioxidant-enzyme activity, suppress lipid peroxidation and normalise renal energy supply. [animal, rat]

Cisplatin model and aged kidney

In rats with cisplatin-induced acute kidney failure, EDL with Epitalon and a kidney complex normalised diuresis, urinary creatinine, glomerular filtration rate and sodium handling. In old rats, diuresis rose about 1.2-1.4 fold and renal antioxidant-enzyme activity rose, with no nephrotoxicity in the tissue. [animal, rat]

Kidney cell cultures

In aging renal cell culture, AED and EDL were reported to raise proliferation, lower p16, p21 and p53 and raise SIRT-6; MMP-14 was reported as the target of T-35 in primary kidney cell cultures. [in vitro]

Kidney explants

In organotypic kidney explants from young and old rats, T-35 was reported to stimulate proliferation and reduce apoptosis, less than the polypeptide complex did. [ex vivo, rat tissue]

Scientific Overview

In short: Ovagen (Glu-Asp-Leu, "EDL") is a three-residue synthetic peptide from the Khavinson bioregulator family; the peer-reviewed experiments on it are all in kidney tissue and kidney cell cultures.

Key research facts

Synthetic Glu-Asp-Leu (EDL) tripeptide from the Khavinson short-peptide lineage, lab code T-35

Studied in rat kidney-injury models for diuresis, creatinine and antioxidant-enzyme markers

Examined in kidney cell cultures for MMP-14, p16, p21, p53 and SIRT-6

Tested side by side with Cartalax (Ala-Glu-Asp) in kidney cultures and aged-rat kidney

Shares its Glu-Asp pair with Pinealon, Epitalon and Chonluten

These points summarise lab themes, not human outcomes.

EDL is Bronchogen (Ala-Glu-Asp-Leu) without its first residue. The Khavinson reviews list it as "Ovagen (EDL)", with a kidney role and a liver role. The papers themselves call it "EDL peptide" or "T-35" and never use the word Ovagen, and the patent behind it, which concerns liver regeneration, does not either. The name collides with an unrelated veterinary hormone product, so it should be searched by sequence.

The kidney work is the substance of the peer-reviewed record on EDL. In rat models of drug-induced and ischemia-related kidney injury, EDL was reported to normalise diuresis and creatinine markers and to preserve antioxidant-enzyme activity. In aged rats it was reported to raise diuresis and sodium excretion with no sign of nephrotoxicity in the tissue. In kidney cell cultures it was reported to raise proliferation, lower p16, p21 and p53 and raise SIRT-6, and to act on MMP-14 as a target.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Glu-Asp-Leu (EDL)

Research focus: Kidney tissue, kidney explants and kidney cell cultures

Evidence base: Rat and cell-culture studies, every one co-authored by the originating group; no human data

Ovagen is a synthetic tripeptide with the sequence Glu-Asp-Leu (EDL), carried in the Khavinson papers under the lab code T-35. The name suggests an ovarian peptide, but it is the trade-style name for EDL and not a tissue claim. All six peptide-specific peer-reviewed papers test kidney tissue and kidney cell cultures, in rat injury models, aged-rat kidney, kidney explants and cell cultures. The liver link comes from a patent. It is supplied as lyophilised powder strictly for in-vitro and preclinical research. Not for human or veterinary use.

At a glance

Compound identity Synthetic short-peptide bioregulator (Khavinson family)

Primary research focus Kidney tissue, kidney explants and kidney cell cultures

Mechanism and receptors Ovagen is studied as a kidney-matched short peptide. The cell-culture data point to senescence markers (p16, p21, p53, SIRT-6) and an MMP-14 target; the animal data are functional kidney readouts.

Experimental models Diuresis, creatinine, GFR and sodium handling in rat gentamicin, ischemia-reperfusion and cisplatin kidney-injury models; Diuresis, sodium excretion, antioxidant enzymes and morphology in old rat kidney.

Molecular characteristics Molecular weight 375.38 Da; sequence Glu-Asp-Leu.

Evidence maturity Tier 3: Limited / anecdotal — Ovagen has a substantial animal record for a short peptide, but all of it is in kidney and all of it comes from one network. The liver pairing rests on a patent, the gut pairing on retail copy, and the name itself appears in no primary paper. There are no human data and no independent replication. It is supplied as unapproved laboratory material.

Research limitations Most published findings come from cell and animal models; they cannot be treated as evidence of human efficacy or safety.

Proposed Mechanism

Ovagen is studied as a kidney-matched short peptide. The cell-culture data point to senescence markers (p16, p21, p53, SIRT-6) and an MMP-14 target; the animal data are functional kidney readouts.

Pathway Effect Why it matters Kidney function markers Diuresis, creatinine, GFR and sodium handling normalised in rat injury models Functional readouts in animals; one research group Antioxidant balance Antioxidant-enzyme activity preserved and lipid peroxidation suppressed in injured kidney A biochemical explanation the authors offer for the functional effects Senescence markers p16, p21 and p53 lowered and SIRT-6 raised in aging renal cell cultures Used as an ageing-model readout; DNA-docking models accompany it MMP-14 target MMP-14 identified as the target of T-35 in primary kidney cell cultures Species not stated in the abstract

Deeper dive for scientific readers

The Khavinson hypothesis is that ultrashort peptides regulate tissue-specific gene expression, with a DNA-binding step. For EDL the supporting data are animal kidney function, culture-level senescence markers and docking that places EDL and Bronchogen at the same DNA site (ctcc). The liver link in the group's review tables is sourced to the patent, not to a journal paper, and there is no peer-reviewed liver study of EDL; the gut link in retail copy has no support in the literature found. All papers share the originating group's authors and no independent replication was found.

Common Questions People Are Asking

What is Ovagen?

Ovagen is the trade-style name used in the Khavinson group's reviews for the synthetic tripeptide Glu-Asp-Leu (EDL), lab code T-35. It is supplied here as a laboratory research powder only.

Is Ovagen an ovarian peptide?

No evidence in the cited literature says so. The name is a label, and every peer-reviewed experiment on EDL is in kidney tissue or kidney cells.

Is it a liver peptide?

The liver pairing comes from a patent on liver regeneration and from the group's review tables, not from a journal paper; no peer-reviewed liver study of EDL was found. No gut link appears in the literature found.

Is there human data on Ovagen?

No human study was found. Ovagen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Ovagen?

Right here - Ovagen is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Ovagen cost?

Ovagen pricing is shown live on this page, per pack size - sealed 10-vial research packs, or single vials where listed (an order needs at least 5 single vials in total, or any 10-vial pack). Shipping is free on orders over $350.

How do I buy Ovagen?

Add the Ovagen pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Ovagen?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Ovagen?

In the United States, Ovagen is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Ovagen has a substantial animal record for a short peptide, but all of it is in kidney and all of it comes from one network. The liver pairing rests on a patent, the gut pairing on retail copy, and the name itself appears in no primary paper. There are no human data and no independent replication. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Diuresis, creatinine, GFR and sodium handling in rat gentamicin, ischemia-reperfusion and cisplatin kidney-injury models

Diuresis, sodium excretion, antioxidant enzymes and morphology in old rat kidney

Proliferation and apoptosis in organotypic kidney explants from young and old rats

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Zamorskii II, Shchudrova TS, Lin'kova NS, et al. Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis. Bull Exp Biol Med 2017. · 2017 · PMID: 28744634 · DOI: 10.1007/s10517-017-3811-1

Zamorskii II, Shchudrova TS, Lin'kova NS, et al. Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure. Bull Exp Biol Med 2015. · 2015 · PMID: 26515176 · DOI: 10.1007/s10517-015-3062-y

Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull Exp Biol Med 2014. · 2014 · PMID: 24958378 · DOI: 10.1007/s10517-014-2540-y

Khavinson VKh, Tarnovskaia SI, Lin'kova NS, et al. Tripeptides slow down aging process in renal cell culture. Adv Gerontol 2014. · 2014 · PMID: 25946838

Zamorskii II, Shchudrova TS, Zeleniuk VG, et al. The influence of peptides on the morphofunctional state of old rats kidneys. Adv Gerontol 2018. · 2018 · PMID: 30607912

Chalisova NI, Lin'kova NS, Nichik TE, et al. Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals. Bull Exp Biol Med 2015. · 2015 · PMID: 26033601 · DOI: 10.1007/s10517-015-2906-9

Khavinson VK, Lin'kova NS, Tarnovskaya SI. Short Peptides Regulate Gene Expression. Bull Exp Biol Med 2016. · 2016 · PMID: 27909961 · DOI: 10.1007/s10517-016-3596-7

PubMed: peer-reviewed literature on Ovagen

ClinicalTrials.gov: registered studies on Ovagen

Ovagen: Wikipedia (search)

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

Sky News Australia: “Backyard peptide boom sparks alarm” (video)

Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

Key Characteristics

Three-residue peptide: Glu-Asp-Leu (EDL), lab code T-35

Bronchogen (Ala-Glu-Asp-Leu) without its first residue

Every peptide-specific peer-reviewed study is in kidney tissue or cells

Liver pairing from a patent; no peer-reviewed liver study

The name appears in review tables, not in the primary papers

Supplied as sealed 10-vial packs of 20 mg lyophilised vials, or as single vials

Specifications

Sequence Glu-Asp-Leu (EDL) Residues 3 Molecular Formula C 15 H 25 N 3 O 8 Molecular Weight 375.38 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Ovagen (EDL): Short-Peptide Bioregulator Research Guide

Ovagen is a name for a peptide, not a description of an organ. The patent behind EDL (WO 2007/139430, with a Russian counterpart) has a Russian priority date of May 2006, concerns liver regeneration, and describes tests in rat liver explants, partial hepatectomy and a toxic-injury model. The kidney papers that make up the peer-reviewed record start in 2014.

Listed CAS numbers differ between sources, so none is published here. The formula C15H25N3O8 and average mass of 375.38 Da are computed from Glu-Asp-Leu and match the compound records in PubChem and ChEBI.

New-U Research Compounds supplies Ovagen as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Zamorskii II, Shchudrova TS, Lin'kova NS, et al. Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis. Bull Exp Biol Med 2017.

Zamorskii II, Shchudrova TS, Lin'kova NS, et al. Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure. Bull Exp Biol Med 2015.

Khavinson VKh, Lin'kova NS, Polyakova VO, et al. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull Exp Biol Med 2014.

Khavinson VKh, Tarnovskaia SI, Lin'kova NS, et al. Tripeptides slow down aging process in renal cell culture. Adv Gerontol 2014.

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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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