Buy Vesugen (KED, T-38) Peptide Bioregulator

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Vial strength 20 mg In stock. Pick one in the selector.

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Form Lyophilised powder Supplied in sealed vials. Storage conditions are listed in the specifications.

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Vesugen

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Scientific Research Context

What the published literature on Vesugen examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Endothelial markers

KED was reported to normalise endothelin-1 expression that was raised in atherosclerotic and restenotic endothelium, and to increase connexin and sirtuin-1 expression. [in vitro]

Ki-67 in vascular cultures

Vesugen was reported to raise Ki-67, which declines with age, in tissue-specific cultures from young and old animals and in dissociated vascular endothelial cultures; docking predicted contact with the MKI67 promoter. [in vitro and in silico]

Neuronal models

In 5xFAD mice, KED and Pinealon were reported to prevent dendritic spine loss, and KED "tended to increase" neuroplasticity. In fibroblast-derived human induced neurons, KED promoted dendrite arborisation and had no effect on mitochondrial activity, lysosomal activity or p16. [animal, in vitro and in silico]

Pineal and stem-cell cultures

Lys-Glu-Asp raised Ki-67 and lowered p53 in pineal organotypic cultures, more in old cultures, and modulated IGF1, FOXO1, TNKS2 and NF-kB expression in human mesenchymal stem-cell cultures. [in vitro]

Scientific Overview

In short: Vesugen (Lys-Glu-Asp, "KED") is a three-residue synthetic peptide from the Khavinson bioregulator family, studied in vascular endothelial, neuronal and stem-cell cultures.

Key research facts

Synthetic Lys-Glu-Asp (KED) tripeptide from the Khavinson short-peptide lineage, lab code T-38

Studied in vascular endothelial cultures for endothelin-1, connexin, sirtuin-1 and Ki-67

Examined in a transgenic mouse model of neuronal spine loss, with Pinealon as comparator

Tested in pineal organotypic cultures and human mesenchymal stem-cell cultures

The shared stem of Livagen, Pancragen, Testagen and Prostamax

These points summarise lab themes, not human outcomes.

KED is the stem of four other products in this group: Livagen is KED plus alanine, Pancragen KED plus tryptophan, Testagen KED plus glycine and Prostamax KED plus proline. Its tissue assignment is vascular. Reviews state that KED was isolated from a polypeptide complex of calf blood vessels, in a sentence that cites a 2024 paper this site has not checked, and the patent concerns capillary resistance and microcirculation.

The best-documented work is in cell culture. In endothelial models it was reported to normalise endothelin-1 expression raised in atherosclerotic-type endothelium and to increase connexin and sirtuin-1 expression; in vascular endothelial cultures it raised Ki-67, which declines with age. In 5xFAD mice, KED "tended to increase" neuroplasticity and KED and Pinealon were reported to prevent dendritic spine loss. Further cell studies report effects in pineal organotypic cultures, human mesenchymal stem-cell cultures and fibroblast-derived induced neurons.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Lys-Glu-Asp (KED)

Research focus: Vascular endothelial cultures; neuronal and stem-cell models

Evidence base: Cell-culture, mouse and in-silico studies from one St. Petersburg network; two small Russian-language human reports not summarised here

Vesugen is a synthetic tripeptide with the sequence Lys-Glu-Asp (KED), carried in the Khavinson papers under the lab code T-38 and which pairs it with vascular tissue; reviews state it was isolated from a polypeptide complex of calf blood vessels. A patent with a May 2006 priority date covers the substance. The experiments are in cell and animal models: endothelial cultures (endothelin-1, connexin, sirtuin-1, Ki-67), a transgenic mouse model of neuronal spine loss, pineal organotypic cultures, mesenchymal stem-cell cultures and induced neurons. It is supplied as lyophilised powder strictly for in-vitro and preclinical research. Not for human or veterinary use.

At a glance

Compound identity Synthetic short-peptide bioregulator (Khavinson family)

Primary research focus Vascular endothelial cultures; neuronal and stem-cell models

Mechanism and receptors Vesugen is studied as a vascular-matched short peptide that may act on endothelial gene expression. The proposed route is nuclear entry and DNA binding; the data are expression readouts and docking.

Experimental models Dendritic spine preservation in 5xFAD mice (with Pinealon); Honey-bee associative learning (reported with Lys-Glu-Asp in one cell and animal paper).

Molecular characteristics Molecular weight 390.39 Da; sequence Lys-Glu-Asp.

Evidence maturity Tier 3: Limited / anecdotal — Vesugen has a preclinical record of endothelial, neuronal, pineal and stem-cell culture work, one transgenic-mouse study and docking, all from one St. Petersburg network and partly in Russian-language journals. Two small human reports exist, are single-group and are not relied on here. There is no randomised trial and no independent replication. It is supplied as unapproved laboratory material.

Research limitations Most published findings come from cell and animal models; they cannot be treated as evidence of human efficacy or safety.

Proposed Mechanism

Vesugen is studied as a vascular-matched short peptide that may act on endothelial gene expression. The proposed route is nuclear entry and DNA binding; the data are expression readouts and docking.

Pathway Effect Why it matters Endothelin-1 and connexin expression Endothelin-1 normalised, connexin and sirtuin-1 raised in endothelial models The core vascular-matching evidence; in vitro Proliferation markers Ki-67 raised in vascular, pineal and other cultures, with larger effects in old cultures Reported across tissues by the same network; not a vascular-specific result Spine and dendrite biology Dendritic spines preserved in a transgenic mouse model; arborisation promoted in induced neurons Neuronal rather than vascular, tested beside Pinealon DNA-contact prediction Docking predicted contact with the MKI67 promoter and DNA binding Computational predictions only

Deeper dive for scientific readers

The Khavinson hypothesis is that ultrashort peptides enter the nucleus and bind promoter sequences. For KED the supporting data are expression readouts in cell culture, one transgenic-mouse study, and docking. The peptide has been co-tested with AED (Cartalax), KE, EDR (Pinealon) and AEDG (Epitalon) in several cell models, and a systematic review lists them as members of one family; no paper found states a derivation among them. All primary literature comes from one St. Petersburg network, much of it in Russian-language journals with English abstracts, and no independent replication was found. Two small human reports exist, both single-group and Russian-language; they are not summarised here.

Common Questions People Are Asking

What is Vesugen?

Vesugen is the name used for the synthetic tripeptide Lys-Glu-Asp (KED), lab code T-38, in the Khavinson short-peptide literature, which pairs it with vascular tissue. It is supplied here as a laboratory research powder only.

How is Vesugen related to Livagen, Pancragen, Testagen and Prostamax?

Each of those is Lys-Glu-Asp with one more residue at the end: alanine for Livagen, tryptophan for Pancragen, glycine for Testagen and proline for Prostamax. That is a sequence observation; the papers do not state a derivation.

What does the research on Vesugen show?

In endothelial cultures it was reported to normalise endothelin-1 and raise connexin, sirtuin-1 and Ki-67. In a transgenic mouse model it was reported to prevent dendritic spine loss, and further cell studies cover pineal, stem-cell and induced-neuron cultures. All of it is preclinical and from one research network.

Is there human data on Vesugen?

Two small Russian-language reports exist; both are single-group and neither is relied on here. No randomised trial was found. Vesugen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Vesugen?

Right here - Vesugen is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Vesugen cost?

Vesugen pricing is shown live on this page, per pack size - sealed 10-vial research packs, or single vials where listed (an order needs at least 5 single vials in total, or any 10-vial pack). Shipping is free on orders over $350.

How do I buy Vesugen?

Add the Vesugen pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Vesugen?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Vesugen?

In the United States, Vesugen is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Vesugen has a preclinical record of endothelial, neuronal, pineal and stem-cell culture work, one transgenic-mouse study and docking, all from one St. Petersburg network and partly in Russian-language journals. Two small human reports exist, are single-group and are not relied on here. There is no randomised trial and no independent replication. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Dendritic spine preservation in 5xFAD mice (with Pinealon)

Honey-bee associative learning (reported with Lys-Glu-Asp in one cell and animal paper)

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Kozlov KL, Bolotov II, Linkova NS, et al. Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis. Adv Gerontol 2016. · 2016 · PMID: 28539025

Khavinson VKh, Tarnovskaia SI, Lin'kova NS, et al. Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging. Adv Gerontol 2014. · 2014 · PMID: 25051766

Khavinson V, Ilina A, Kraskovskaya N, et al. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel) 2021. · 2021 · PMID: 34071923 · DOI: 10.3390/ph14060515

Chalisova NI, Lopatina NG, Kamishev NG, et al. Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells. Bull Exp Biol Med 2012. · 2012 · PMID: 22977872 · DOI: 10.1007/s10517-012-1768-7

Ashapkin V, Khavinson V, Shilovsky G, et al. Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. Mol Biol Rep 2020. · 2020 · PMID: 32399807 · DOI: 10.1007/s11033-020-05506-3

Kraskovskaya N, Linkova N, Sakhenberg E, et al. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. Int J Mol Sci 2024. · 2024 · PMID: 39518916 · DOI: 10.3390/ijms252111363

Khavinson V, Linkova N, Dyatlova A, et al. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. Cells 2022. · 2022 · PMID: 36611900 · DOI: 10.3390/cells12010106

Khavinson VK, Popovich IG, Linkova NS, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules 2021. · 2021 · PMID: 34834147 · DOI: 10.3390/molecules26227053

PubMed: peer-reviewed literature on Vesugen

ClinicalTrials.gov: registered studies on Vesugen

Vesugen: Wikipedia (search)

WebMD: consumer health reference

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Key Characteristics

Three-residue peptide: Lys-Glu-Asp (KED), lab code T-38

The shared stem of Livagen, Pancragen, Testagen and Prostamax

Endothelial, neuronal, pineal and stem-cell culture data; one transgenic-mouse study

Spelled "Vezugen" in some Russian-transliteration abstracts

Two small human reports exist and are not relied on; no randomised trial

Supplied as sealed 10-vial packs of 20 mg lyophilised vials, or as single vials

Specifications

Sequence Lys-Glu-Asp (KED) Residues 3 Molecular Formula C 15 H 26 N 4 O 8 Molecular Weight 390.39 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Vesugen (KED): Short-Peptide Bioregulator Research Guide

Vesugen has been co-tested with several of the group's other short peptides. The patent covering H-Lys-Glu-Asp-OH (EP 2024387 B1) has a priority date of May 2006 and was filed in Europe that December; PubMed papers on it start in 2008. Its compound record is in PubChem under the name Lysyl-glutamyl-aspartic acid, and a name search for "vesugen" there returns nothing, so look it up by sequence.

Listed CAS numbers could not be confirmed against the registry, so none is published on this page. The formula C15H26N4O8 and average mass of 390.39 Da here are computed from the sequence and match the compound record.

New-U Research Compounds supplies Vesugen as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Kozlov KL, Bolotov II, Linkova NS, et al. Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis. Adv Gerontol 2016.

Khavinson VKh, Tarnovskaia SI, Lin'kova NS, et al. Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging. Adv Gerontol 2014.

Khavinson V, Ilina A, Kraskovskaya N, et al. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel) 2021.

Chalisova NI, Lopatina NG, Kamishev NG, et al. Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells. Bull Exp Biol Med 2012.

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Research guide Vesugen research guide Vesugen is studied as a vascular-matched short peptide that may act on endothelial gene expression. Read the guide →

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